Effect of processing techniques on new poly(ε-caprolactone)-embelin microparticles of biomedical interest

PABLO R. CORTEZ TORNELLO; GABRIELA E. FERESIN; ALEJANDRO TAPIA; MONIKA DZIECIUCH; TERESITA R. CUADRADO; GUSTAVO A. ABRAHAM

ADVANCES IN POLYMER TECHNOLOGY

JOHN WILEY & SONS INC

Lugar: New York; Año: 2018 vol. 37 p. 1570 - 1580

0730-6679

Poly(E-caprolactone) microparticles containing embelin (PCLE), are prepared by electrohydrodynamic atomization (EHDA) and emulsion solvent evaporation techniques. The microparticles are characterized in terms of drug state, drug loading capacity, encapsulation efficiency, morphology and in vitro release in mediums with different pH. Physicochemical, morphological and thermal characterization is presented. Kinetic analysis of release curves is also performed. EHDA microparticles present higher size, surface area, and encapsulation efficiency. The release profiles combine a high initial release, followed by a slow controlled release stage. Electrosprayed PCLE presented characteristics, size and release profiles that could be attractive for the development of microcarriers for pulmonary administration of embelin.