Development and testing of vitamin coated titanium dioxide nanoparticles with improved biocompatibility

VAUDAGNA, V.; ZOPPI, A.; BECERRA, M.C.; AIASSA, V.; SILVERO COMPAGNUCCI, J.

Mar del Plata

Congreso; Reunión anual de Sociedades Biocientíficas-SAIC-SAFE-SAB-SAP 2019; 2019

Titanium dioxide nanoparticles are widely used in cosmetics, especially in sunscreens due to their capacity to absorb UV harmful wavelengths. However, their biocompatibility remains controversial. In this work, titanium dioxide nanoparticles were functionalized with antioxidants vitamins (vitamin B2 and vitamin C) and the effect under simulated sun radiation was compared to bare nanoparticles, in prokaryotic cells.In general, cell viability decreased significantly after being exposed to titanium dioxide nanoparticles and light for 6h, while reactive oxygen species, oxidation of proteins and lipids increased. Results suggest that this unwanted side effect could be avoided by functionalization with vitamin B2 through a rapid sol-gel method, while vitamin C conjugation did not produce the protective desired effect, possibly due to a red shift in its light absorbance.