INVESTIGADORES
ZOPPI Ariana
artículos
Título:
Studies of pilocarpine:carbomer intermolecular interactions
Autor/es:
ZOPPI A.; GARRO LINCK Y.; MONTI G.A.; GENOVESE D.; JIMÉNEZ KAIRUZ A.F.; MANZO R. H.; LONGHI M. R.
Revista:
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2012 vol. 427 p. 252 - 259
ISSN:
0378-5173
Resumen:
The interactions between pilocarpine (PIL) and the anionic polyelectrolyte carbomer (CBR)
were investigated. The effects of the chemical interactions on the chemical stability of the
drug also were evaluated. The binary system was characterized by nuclear magnetic
resonance techniques, fourier-transform infrared spectroscopy, X-ray powder diffraction,
scanning electron microscopy and thermal analysis. The experiments showed that the
complex, prepared by freeze-drying, is a solid amorphous form different from its precursors,
thereby offering an interesting alternative for the preparation of extended release matrices.
The solution stability of PIL was studied at pH 7 and 8, at 70 ºC. The PIL solution stability
was evaluated alone and in the presence of CBR. Results indicated that the drug in the
presence of the polymer is 3.3 and 3.5 times more stable, at pH 7 and pH 8, respectively, than
the drug without CBR. The activation energy and the frequency factor, according to Arrhenius
plot, were estimated to be 13.9 ± 0.4 and 14.8 ± 0.5 kcal/mol, and 6.1 ± 0.3 and 7.6 ± 0.3,
with and without the polymer, respectively.
with and without the polymer, respectively.