Unexpected Result in the Catalytic Solvent-free Multicomponent Synthesis of 2-Amino-3-cyano-4H-chromene

V. PALERMO; A.A. SOSA; T.S. RIVERA; L.R. PIZZIO; G.P. ROMANELLI

Organic Preparations and Procedures International

Taylor & Francis

Año: 2019 vol. 51 p. 443 - 455

0030-4948

Multicomponent reactions (MCRs) are efficient and effective methods for the sustainable and diversity-oriented synthesis of heterocycles. In a green chemistry context, the traditional methods of performing chemical synthesis are unsustainable, and MCRs provide an important solution since they are more efficient, cost-effective, and less wasteful. A known MCR for example is the condensation between aldehyde, malononitrile, and phenol or naphthol to give 2-amino-3-cyano-4H-chromenes.In this article, we present a study of the MCR among benzaldehyde, malononitrile, and 2-naphthol, catalyzed by zirconia/phosphotungstic acid composites, to obtain 2-amino-3-cyano-4H-chromene or 14-aryl-14H-dibenzo[a,j]xanthen depending on the reaction conditions.