Software Application To Monitor Neurodegenerative Motor Disease

BONACCORSO P.; CABRERA R.

Macau

Conferencia; BIT´s 8th World Gene Convention; 2017

BIT´s Conventions

1. Software application nowadays is a valuable tool to monitor movement disorders associated with neurodegenerative diseases. Automated development has been implemented to evaluate motor signs including voluntary and involuntary actions like muscle problems, rigidity, dystonia, chorea, tremors, bradykinesia, gait disorders, and impaired posture and balance. In particular, this approach has increased the number of parameters assessed, what is more, it includes a statistic module to make inferences and a graphic interface to present results. In addition, there is no need for special equipment for it to function.2. 17β-Estradiol chronic administration on an animal model of Parkinson Disease (PD) was implemented to evaluate forelimb motor parameters by means of software. Program application increased the number of parameters and accurately evaluated them. What is more, it contributed on describing nigrostriatal dopamine dysfunction and revealing 17β-Estradiol´s neuroprotective effects in vivo in PD. Special attention should be placed on 17β-Estradiol as a neuroprotective drug. When administrated on hemiparkinsonian animals, they exhibited less neurodegenerative signs in every test performance. Showing compensatory mechanism on motor dysfunction by increasing balance, mobility, speed and decreasing bradykinesia and stiffness. Particularly in reference to forelimb motor parameters, we noticed an improvement in the number of adjusting steps and less latency in the initial time. Also, there is a higher average energy that could be enhancing stepping time and forelimb movement magnitude. In conclusion, this software development and implementation is a worthy tool to in vivo infer on movement disorders, specially forelimb akinesia. By applying it, we obtained a new sensitive approach in the effect of 17β-Estradiol as a neuroprotective drug in PD. BiographyMaria Paula Bonaccorso Marinelli, female, bioengineer, graduated Universidad de Mendoza in 2013. In 2013 she received the National Academy of Engineering Award. From 2014-2015 she worked with web applications on a project called SMS MAMÁ and she presented the results in Argentina at the VIII Primary Health Congress and the XX Biomedical Engineering Congress, and in Chile on the 1º International Conference of Latinas in Computing. In the same period, she made an internship working on an animal model of hemiparkinsonism induced by a neurotoxin called 6-Hydroxydopamine in the Biomedical Research Institute (INBIOMED-IMBECU-CONICET) under the direction of Dr. Ricardo Cabrera. The firsts results of that internship were exposed on the Argentinian Society of Clinical Research and published on the Argentinian Journal ?Medicine?.On 2016 she was awarded a doctoral fellowship by the National Council of Scientific and Technical Research to work at INBIOMED. She was admitted to performing the doctoral degree in Neuroscience at Universidad Nacional de Córdoba under de direction of Dr. Ricardo Cabrera. She studies the neuroprotective effect of estrogen against dopaminergic functional modifications induced by 6-Hydroxydopamine in male rats. The first preliminary results were presented in the Argentinian Society of Clinical Research and published on the Argentinian Journal ?Medicine?. One of the software´s developed was presented in the Latin American Congress of Bioengineering in Colombia and was published this April in the International Federation of Medical and Biological Engineering Proceedings.