Allopregnanolone promotes angiogenesis and inhibits apoptosis in the corpora lútea in rat ovarían cycíe

LACONI M.; CABRERA R.; PARBORELL F.

Edimburgo

Congreso; World Congress of Reproductive Biology 2014.; 2014

Background / Purpose: We report the effect of allopregnanolone (ALLO, 3α-hydroxy-5α-pregnan-20-one), one of the best characterized neurosteroids, on the morphological changes and in angiogenesis in ovary of cycling rats. ALLO has several effects on the reproductive biology of the female. Previously, we demonstrated that ALLO inhibited ovulation and secretion of LH and Pg, increased the PRL levels and inhibited the female receptivity. ALLO also inhibited apoptosis in corpus luteum. Now, we report the ALLO effects on Angiogenesis (the formation of new blood vessels from preexisting vessels, develops cyclically in the ovary and is vital for the formation of reproductive structures in ovulation and corpus luteum formation). This process has been studied in conditions such as cancer, but under physiological conditions angiogenesis occurs in tissues where cyclic changes as ovarian and uterine endometrium occurs. Angiogenesis is regulated by various protein factors. These angiogenic factors are heavily regulated and proper vascularization of a tissue is dependent on a close relationship between them. The objective of this work was to analyze the effect of ICV 6um ALLO in morphologic changes in ovarian structures and in angiogenesis in ovarian vascular stroma during the estrus cycle. Main conclusion: In conclusion, the results reported here are the first evidence of the effect of ICV administration of ALLO in the development and stability of blood vessels in the ovary. We would propose, in a new experimental model, ALLO as a molecule for controlling inappropriate development of ovarian structures and highlighting their role in ovarian physiology.