INVESTIGADORES
GARNERO Claudia
artículos
Título:
SULFAMETHOXAZOLE:HYDROXYPROPYL-B-CYCLODEXTRIN COMPLEX: PREPARATION AND CHARACTERIZATION
Autor/es:
CLAUDIA GARNERO; VIRGINIA AIASSA; MARCELA LONGHI
Revista:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2012 vol. 63 p. 74 - 79
ISSN:
0731-7085
Resumen:
A complex of sulfamethoxazole (SMX) and hydroxypropyl-B-cyclodextrin (HP-B-CD) was developedand characterized in order to investigate their interactions in aqueous solution and the solid state. The SMX solubility was significantly increased upon complexation with HP-B-CD, with the solubility isotherm being an AN type due to the presence of aggregates and the stability constant calculated for a1:1 complex being 302 ± 3 M-1. Fourier-transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) experiments were used to compare the freeze-dried system with a physical mixture,and demonstrated the complex formation in the solid state. The differential scanning calorimetry (DSC)and thermogravimetric analysis (TGA) showed that the thermal stability of SMX was enhanced in the presence of HP-B-CD.
