SIMVASTATIN-LOADED BIOACTIVE LIPID NANOPARTICLES AS A DRUG REPURPOSING STRATEGY AGAINST LUNG CANCER

MORENO, AILIN; MONTOTO, S. SCIOLI; GAMBARO, ROCÍO; CISNEROS, JOSÉ S.; RUIZ, M.E.; CHAIN, CECILIA Y.; ISLAN, G.A.; RODENAK KLADNIEW B

MAR DEL PLATA

Congreso; REUNION ANUAL DE SOCIEDADES DE BIOCIENCIAS; 2023

SAIC - SAB -AAFE - AACyTAL

In recent years, researchers have explored new uses for affordablemedications approved for other diseases, a strategy called “drugrepurposing”. Statins (lipid-lowering drugs) exhibited anticancereffects in several cancer cell types; however, their therapeutic usehas faced limitations related to solubility and toxic side effects. Nanotechnologyhas emerged as a powerful tool to overcome thesedrawbacks. Here, we developed Simvastatin (SV)-loaded lipidnanoparticles (LNP) to deliver and enhance SV activity against lungcancer cells. Two types of LNPs, in terms of composition, were producedby the ultrasonication method: LNP containing (NLC) or not(SLN) liquid lipids (LL) in the core. The morphology, size, z-potential(z-pot), and polydispersity (PI) were measured by DLS and TEM.Standard triglyceride (Crodamol®) or bioactive terpenes (linalool-LN-, geraniol -GN-, cineole -CN-) were used as LL. All LNPs exhibiteda spherical shape with sizes from 115 to 165 nm in a narrowdistribution (PI