Gene expression and ChIP-seq data analyses confirm FOXM1 as a player in prostate cancer biology

BRANDANI, JAVIER; BIZZOTTO, JUAN; ABBATE, MERCEDES; LEONARDI, DAIANA; GUERON, GERALDINE; VAZQUEZ, ELBA; COTIGNOLA, JAVIER

Mar del Plata

Congreso; Reunión Anual de Biociencia 2019; 2019

Sociedad Argentina de Investigación Clínica

Dysregulation of the androgen receptor (AR) and glucocorticoid receptor (GR) expression is responsible, at least in part, for the development and progression of prostate cancer (PCa). GR might also have oncogenic or tumor suppressor activities depending on the presence/absence of AR and other regulatory cofactors such as the Forkhead Box (FOX). We previously showed the involvement of FOXM1 in cell migration, proliferation, viability, morphology, apoptosis, and the modulation of the transcriptional activity of GR and AR in PCa cells. The aim of this study was to validate the potential use of FOXM1 as a biomarker for PCa and understand the molecular mechanisms involved. We took advantage of public repositories to study the association between FOXM1 expression and the clinico-pathological characteristics of patients with PCa. We downloaded raw transcriptome data from 3 datasets GSE54460, GSE94767 and PRAD-TCGA. The expression of FOXM1 and AR were positively correlated with Gleason score (p