Associations of Cumulative Sun Exposure and Phenotypic Characteristics with Histologic Solar Elastosis

THOMAS, NANCY; KRICKER, ANNE; FROM, LYNN; BUSAM, KLAUS; MILLIKAN, ROBERT; RITCHEY, MARY; ARMSTRONG, BRUCE; LEE-TAYLOR, JULIA; MARRETT, LORAINE; ANTON-CULVER, HODA; ZANETTI, ROBERTO; ROSSO, STEFANO; GALLAGHER, RICHARD; DWYER, TERENCE; GOUMAS, CHRIS; KANETSKY, PETER; BEGG, COLIN; ORLOW, IRENE; WILCOX, HOMER; PAINE, SUSAN; BERWICK, MARIANNE; MUJUMDAR, URVI; HUMMER, AMANDA; MITRA, NANDITA; ROY, PAMPA; CANCHOLA, REBECCA; CLAS, BRIAN; COTIGNOLA, JAVIER; MONROE, YVETTE; LITCHFIELD, MELISA; TUCKER, PAUL; STEPHENS, NICOLA; SWITZER, TERESA; THEIS, ELIZABETH; CHOWDHURI, NOORI; VANASSE, LOUISE; PURDUE, MARK; NORTHRUP, DAVID; SACERDOTE, CARLOTTA; LEIGHTON, NANCY; GILDEA, MAUREEN; GRUBER, STEPHEN; BONNER, JOSEPH; JETER, JOANNE; KLOTZ, JUDITH; WEISS, HELEN; MATTINGLY, DIANNE; PLAYER, JON; TSE, JESSICA; REBBECK, TIMOTHY; KANETSKY, PETER; WALKER, AMY; PANNOSSIAN, SAARENE; MOHRENWEISER, HARVEY; SETLOW, RICHARD; LEE-TAYLOR, JULIA; MADRONICH, SASHA

CANCER EPIDEMIOLOGY, BIOMARKERS & PREVENTION

AMER ASSOC CANCER RESEARCH

Lugar: Philadelphia; Año: 2010 vol. 19 p. 2932 - 2941

1055-9965

BACKGROUND: Solar elastosis adjacent to melanomas in histologic sections is regarded as an indicator of sun exposure, although the associations of UV exposure and phenotype with solar elastosis are yet to be fully explored. METHODS: The study included 2,589 incident primary melanoma patients with assessment of histologic solar elastosis in the population-based Genes, Environment, and Melanoma study. Ambient erythemal UV (UVE) at places of residence and sun exposure hours, including body site-specific exposure, were collected. We examined the association of cumulative site-specific and non-site-specific sun exposure hours and ambient UVE with solar elastosis in multivariable models adjusted for age, sex, center, pigmentary characteristics, nevi, and, where relevant, body site. RESULTS: Solar elastosis was associated most strongly with site-specific UVE [odds ratio (OR) for top exposure quartile, 5.20; 95% confidence interval (95% CI), 3.40-7.96; P for trend