Diffraction enhanced imaging and X-ray flourescence microtomography for analyzing biological simples

ROCHA, H.S.; G.R. PEREIRA; M.J. ANJOS; P. FARIA; G. KELLERMANN; C.A. PÉREZ; G. TIRAO; MAZZARO, I.; GILES, C.; LOPES, R.T.

X-RAY SPECTROMETRY

John Wiley & Sons, Ltd.

Lugar: INGLATERRA; Año: 2007 vol. 36 p. 247 - 253

0049-8246

In this work breast tissue samples were investigated in order to verify the distribution of certain elements by X-ray fluorescence microtomography (XRFCT) correlated with the characteristics and pathology of each tissue observed by Diffraction Enhanced Imaging (DEI). The DEI system can show details in low attenuation tissues. It is based on the contrast imaging obtained by extinction, diffraction and refraction characteristics and can improve reduction in false positive and false negative diagnoses. XRFCT allows mapping of all elements within the sample, since even a minute fluorescence signal can be detected. DEI imaging techniques revealed the complex structure of the disease, confirmed by the histological section, and showed micro structures in all planes of the sample. The XRFCT showed the distribution of Zn, Cu and Fe at higher concentration.