Lectin binding pattern in the small intestine of rabbits intoxicated with Solanum glaucophyllum

ZANUZZI CN; BARBEITO CG; FONTANA PA; PORTIANSKY EL; GIMENO EJ

Poisonous Plants: Global Research and Solutions

CABI Publishing

Año: 2007; p. 285 - 291

Enzootic calcinosis (EC) in ruminants is a chronic plant intoxication characterized by the calcification of soft tissues and loss of bdy condition. Solanurn glaucophyllum (Sg) is one of the plants that has been recognized as responsible for inducing chronic systemic calcinosis. Vitamin D is not only involved in calcium homeostasis but also has been implicated in such essential and varying processes as cell differentiation and proliferation. The small intestine is one of the target organs of vitamin D, in which it stimulates calcium absorption In addition to this contribution to mineral homeostasis, vitamin D also affects intestinal proliferation and differentiation by inducing the synthesis of compounds known as polyamines, which regulate both processes. Lectins are carbohydrate-binding proteins which can be used to localize and identify specific terminal carbohydrate residues. The purpose of this study is to analyze the intestinal carbohydrate expression under the effect of the hypervitarninosis D induced by Sg intoxication, using lectmhistochernistry (LHC).