Fetal learning about ethanol: Empirical arguments against “safe” amounts of prenatal ethanol exposure.

P. ABATE; M. PUETA; SPEAR N.E.; MOLINA J.C.

EXPERIMENTAL BIOLOGY AND MEDICINE

SOC EXPERIMENTAL BIOLOGY MEDICINE

Año: 2008 vol. 233 p. 139 - 154

1535-3702

Near-term fetuses of different mammalian species, including humans, exhibit functional sensory and learning capabilities. The neurobiological literature indicates that the unborn organism processes sensory stimuli present in the amniotic fluid, retains this information for considerable amounts of time, and is also capable of associating such stimuli with biologically relevant events. This research has stimulated studies aimed at the analysis of fetal and neonatal learning about ethanol, a topic that constitutes the core of the present review. Ethanol has characteristic sensory (olfactory, taste, and trigeminal) attributes and can exert pharmacologic reinforcing effects. Thestudies under examination support the hypothesis that low to moderate levels of maternal ethanol intoxication during late pregnancy set the opportunity for fetal learning about ethanol.These levels of prenatal ethanol exposure do not generate evident morphologic or neurobehavioral alterations in the offspring, but they exert a significant impact upon laterethanol-seeking and intake behaviors. Supported by preclinical and clinical findings, this review contributes to strengthening the case for the ability of prenatal ethanol exposure to haveeffects on the postnatal organism.