Advances in Photocatalytic Organic Synthetic Transformations in Water and Aqueous Media

BARATA, SEBASTIAN; YERIEN, DAMIAN E.; AL POSTIGO

ACS Sustainable Chemistry and Engineering

AMERICAN CHEMICAL SOCIETY

Lugar: WASHINGTON; Año: 2021 vol. 9 p. 10016 - 10047

2168-0485

doi.org/10.1021/acssuschemeng.1c03384Advances in visible light-photocatalyzed preparative syntheticorganic transformations in water or aqueous media are studied. Both theconvenience of visible light photocatalytic strategies to achieve synthetic organictransformations and the employment of water or aqueous mixtures make thisapproach a very resourceful methodology. Mechanistic aspects for suchphotocatalyzed processes are discussed. The effects of water in the stereoselectivityof some reactions and considerations regarding the improvedenantioselectivity in chiral catalytic photoredox reactions are manifested withthe use of water. The use of water as a result of a protocol improvement orenvironmentally friendlier methodology as compared to the same reactionperformed in organic solvents are also considered. All these combined effects ofwater as a reaction medium or its very presence in photocatalytic reactions havean ultimate goal which is to diminish the environmental impact of synthetic andphotocatalytic processes. This perspective highlights the progress and state ofthe art organic transformations realized by photocatalytic techniques in water or aqueous systems as well as water as a reactant. Inthis regard, aromatic substitution reactions, radical additions to carbon−carbon double bonds, photooxidation reactions,decarboxylation processes, and miscellaneous reactions are presented.