Transition metal- and organophotocatalyst-free perfluoroalkylation reaction of amino(hetero)aromatics initiated by the complex (TMEDA) I.I3 and visible light

DAMIÁN YERIEN; ROMINA CONDE; BRUNO CAMPS; BARATA VALLEJO, S; BEATRIZ LANTAÑO; AL POSTIGO

Royal Society of Chemistry Advances

ROYAL SOCIETY OF CHEMISTRY

Lugar: Oxford-doi: 10.1039/c6ra24786e; Año: 2017 vol. 2017 p. 266 - 274

2046-2069

doi: 10.1039/c6ra24786eRadical initiation for the perfluoroalkylation reaction of amino(hetero)aromatics has been accomplished employing the complex (TMEDA) I.I3 and visible light. This methodology circumvents the use of metal(organo)catalysts and relies on the well-known iodine atom reaction with perfluoroalkyl iodides to generate perfluoroalkyl radicals RF. Biologically-relevant substrates are easily substituted with RF moieties employing a mild and environmentally benign radical strategy starting from readily-available perfluoroalkyl iodides RFI