INVESTIGADORES
POSTIGO Jose Alberto
artículos
Título:
Late-stage Electron-catalyzed Perfluoroalkylation of Coumarin Derivatives. Thermal Fluoroalkyl Radical Production from Sodium Perfluoroalkyl Sulfinate Salts
Autor/es:
ROSARIO TORVISO; MANSILLA DANIELA; GARCIA, SELVA; BARATA VALLEJO, S; BEATRIZ LANTAÑO; AL POSTIGO
Revista:
JOURNAL OF FLUORINE CHEMISTRY
Editorial:
ELSEVIER SCIENCE SA
Referencias:
Lugar: Amsterdam-10.1016/j.jfluchem.2017.03.005; Año: 2017 vol. 197 p. 42 - 48
ISSN:
0022-1139
Resumen:
10.1016/j.jfluchem.2017.03.005Novel and high-yielding protocols for the late-stage synthesis of 3-perfluoroalkyl-substituted coumarin derivatives employing either perfluoroalkyl iodides RFI or sodium perfluoroalkylsulfinate salts NaSO2RF as perfluoroalkyl RF radical precursors is presented. The electron-catalyzed methodologies make use of two comparative and parallel protocols as an entry to the production of RF radicals: (i) from NaSO2Rf sources and the thermal tert-butylhydroperoxide (TBHP) radical initiation in MeCN : CH2Cl2 as organic solvent mixture, and (ii) from commercial RFI and the photoorganocatalyst anthraquinone-2-sulfonic acid as the room-light initiation process in DMF : CH2Cl2 as mixture of solvents.
