Synthetic Strategies for Fluorosulfonylated Compounds. Applications to Click Chemistry Reactions

SEBASTIAN BARATA VALLEJO; YERIEN, DAMIAN E.; AL POSTIGO

CATALYSIS SCIENCE AND TECHNOLOGY

ROYAL SOCIETY OF CHEMISTRY

Lugar: CHICHESTER; Año: 2023 vol. 13 p. 2597 - 2616

2044-4753

The syntheses and applications of fluorosulfonylated organic compounds have flourished in the last ten years due to their versatility to participate in click chemistry (SuFEx) reactions. Also, organic architectures that combine the SO2F group and other ancillary functional moieties such as olefin, alkyne, etc. (i.e.: bis-electrophiles) have augmented the applications and diversity of the end compounds. To that effect, the association of an alkyne functionality and the Suffexable group within one structure, was shown to encompass two-in-one click chemistry sequential protocols with the aim of building on the diversity of scaffolds by two consecutive click processes. We next examine the syntheses of (hetero)aromatic-, alkyl-, alkenyl-, and alkynyl sulfonyl fluorides, -keto-sulfonyl fluorides, and the syntheses of compounds bearing N-SO2F and O-SO2F bonding (Tables 1-4) through diverse catalytic methods, illustrating examples of their SuFEx click chemistry and other ancillary functional group reactivity