INVESTIGADORES
POSTIGO Jose Alberto
artículos
Título:
Transition Metal-free Photoorganocatalytic Fluoroalkylation Reactions of Organic Compounds
Autor/es:
SEBASTIAN BARATA VALLEJO; DAMIÁN YERIEN; BEATRIZ LANTAÑO; AL POSTIGO
Revista:
CURRENT ORGANIC CHEMISTRY
Editorial:
BENTHAM SCIENCE PUBL LTD
Referencias:
Lugar: Oak Park-doi:10.2174/1385272820666160614080432; Año: 2016 vol. 20 p. 2838 - 2847
ISSN:
1385-2728
Resumen:
10.2174/1385272820666160614080432The generation of perfluoroalkyl radicals (RF?) by means of photocatalysis is a more suitable route than the established methods employing chemical initiators, like azo or peroxide compounds or the use of transition metals. The photocatalytic reaction conditions can tolerate a wide range of functional groups and, therefore, can be applied to the late-stage modification of bioactive molecules. Organic photocatalysts (POC), in the absence of transition metals, can suffer electron-exchange reactions, yielding RF radicals. RF radical production without the assistance of transition metals through the employment of POC will be described, applying this methodology to studying classical examples.
