Advances in metal-assisted non-electrophilic fluoroalkylation reactions of organic compounds

BEATRIZ LANTAÑO; TORVISO, M.R.; BONESI, SERGIO M.; BARATA VALLEJO, S; POSTIGO, A.

COORDINATION CHEMISTRY REVIEWS

ELSEVIER SCIENCE SA

Lugar: Amsterdam http://dx.doi.org/doi:10.1016/j.ccr.2014.11.004; Año: 2015 vol. 285 p. 76 - 108

0010-8545

Metal-assisted trifluoromethylation and perfluoroalkylation reactions are probably one of the first approaches employed to achieve fluoroalkyl-group substitutions of organic substrates through the use of metals such as copper. Fluoroalkylation reactions of both aromatic and aliphatic substrates involving the employment of perfluoroalkyl halides RfX in conjunction with metallic species, and nucleophilic fluoroalkylating reagents in the presence of metals or organometallic species will be studied. Fluoroalkylation reactions utilizing electrophilic fluoroalkylating reagents in the presence of transition metals or trifluoromethylthiolation reactions will not be the subject of this article. Recently-emerging literature (2011-present), with special emphasis on updates from previous review articles on the metal-mediated fluoroalkylation of aromatic substrates will be dealt with.