INVESTIGADORES
POSTIGO Jose Alberto
artículos
Título:
Benign Perfluoroalkylation of Aniline Derivatives through Photoredox Organocatalysis under Visible Light Irradiation
Autor/es:
BARATA-VALLEJO, S.; DAMIÁN YERIEN; A POSTIGO
Revista:
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Editorial:
WILEY-V C H VERLAG GMBH
Referencias:
Lugar: Weinheim, DOI: 10.1002/ejoc.201501189; Año: 2015 vol. 2015 p. 7869 - 7875
ISSN:
1434-193X
Resumen:
DOI: 10.1002/ejoc.201501189 In this work, we present a room light- or solar-initiatedtransition metal-free radical homolytic aromatic substitution (HAS)reaction of aniline derivatives with perfluoroalkyl moieties employingperfluoroalkyl halides as readily-available perfluoroalkyl sources inthe presence of cesium carbonate as base and inexpensive RoseBengal as organophotocatalyst in MeCN as solvent, renderingperfluoroalkyl-substituted aniline derivatives in good-to-excellentyields, even upon scaling up. Although the mechanism of thisreaction is still under investigation, we shall present some evidencebased on competitive substitution rate experiments that cast somelight into the reaction intermediates.
