INVESTIGADORES
POSTIGO Jose Alberto
artículos
Título:
Perfluorobutylation of benzo(hetero)arenes in aqueous media
Autor/es:
BEATRIZ LANTAÑO; BARATA VALLEJO, S; TORVISO, M.R.; A POSTIGO; GARCIA, SELVA; TINNIRELLO, ALDANA
Revista:
biointerface research in applied chemistry
Editorial:
BIOINTERFACE RESEARCH
Referencias:
Año: 2014 vol. 4 p. 861 - 864
ISSN:
2069-5837
Resumen:
Perfluorobutylation of a series of benzo(hetero)aromatic compounds without formal leaving groups is achieved efficaciously in organic solvent: water mixtures under photostimulation. The methodology is compared to previously reported trifluoromethylation strategies of these nuclei in terms of product yields and regioselectivity. The reaction is a radical homolytic aromatic substitution process, where the perfluoroalkyl-substituted cyclohexadienyl radical intermediate is first oxidized and then a proton transfer sequence ensues the products.
