Recent Advances in Trifluoromethylation Reactions with electrophilic trifluoromethylation reagents

BARATA-VALLEJO, S.; BEATRIZ LANTAÑO; AL POSTIGO

CHEMISTRY-A EUROPEAN JOURNAL

WILEY-V C H VERLAG GMBH

Lugar: Weinheim-DOI : 10.1002/chem.201404005; Año: 2014 vol. 20 p. 16806 - 16829

0947-6539

-(trifluoromethyl)dibenzothiophenium tetrafluoroborate), Yagupolskii´s (trifluoromethyldiarylsulfonium salts), Shreeve´s can undergo ET processes affording radicals that expand the scope of substrates other than conventional nucleophiles that can undergo reaction. In this account, we shall discuss the trifluoromethylation reactions of diverse families of organic substrates of biological interest as a means to comparing the reagents scope and best reaction conditions. Some of these reactions do need the assistance of metals or metal-organocatalysts; some others do not. Some require additives and catalysts to promote the fluoroalkylation reaction, but invariably all are initiated and carried out by electrophilic trifluoromethylating species Togni reagent