New and bioactive polyketides from Hawaiian marine-derived fungus Trichoderma sp. FM652

UZ ZAMAN, K. H. A.; WU, X.; SAROTTI, A.M.; CAO, S.*

NATURAL PRODUCT RESEARCH

TAYLOR & FRANCIS LTD

Lugar: Londres; Año: 2022 vol. 36 p. 1 - 7

1478-6419

Two new sorbicillinoid derivatives (1 and 2), together with ten other related compounds (3?12) were isolated from a Hawaiian marine fungal strain Trichoderma sp. FM652. The structures of compounds 1 and 2, including the absolute configuration, were elucidated by extensive analysis of NMR spectroscopy, HRESIMS and electronic circular dichroism (ECD) data. Compounds 6?12exhibited significant anti-proliferative activity against ovarian cancer cell line A2780, with the IC50 values ranging from 0.5 to 8.07 lM. Moreover, compounds 1, 7 and 8 showed significantinhibition against NF-jB with IC50 values of 13.83, 24.4 and 14.63 mM, respectively. Compounds 6, 9 and 12 also demonstrated moderate inhibitory activity against S. aureus and methicillin resistant S. aureus with the MIC values in the range of 10?40 lg/mL