NF-κB inhibitory, antimicrobial and antiproliferative potentials of compounds from Hawaiian fungus Aspergillus polyporicola FS910

WANG, C.; UZ ZAMAN, K. H. A.; SAROTTI, A.M.; WU, X.; ZHENG, S. L.; CAO, S.*

3BIOTECH

SPRINGER

Lugar: Washington; Año: 2021 vol. 11

Bioassay-guided experimental design and chromatographic analysis led to the isolation and identiication of ten compounds (1?10) including two unusual sulfur-containing curvularin macrolides (1 and 2) from a Hawaiian fungal strain Aspergillus polyporicola FS910. Compounds 1 and 2 are rare curvularin macrolides each with a ive-membered cyclic sulfur-containingmoiety. The structures of the compounds were identiied by HRESIMS, NMR spectroscopy, X-ray crystallography, ECD and DFT energy calculation, as well as comparing with previous literatures. Compounds 4, 6 and 8 were active against TNF-α-induced NF-κB inhibitory activity with IC50 values of 26.45, 5.41 and 15.8 µM, respectively. Compounds 3 and 5?8 exhibited anti-proliferative activity against HT1080, T46D, and A2780S cell lines, with IC50 values ranging from 2.48 to 29.17 μM.Additionally, Compound 3 showed promising antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA), Bacillus subtilis, Escherichia coli and Candida albicans. Moreover, when tested in combination with antibiotic adjuvant disuliram [4 µg/mL], compounds 4, 5 and 10 also displayed signiicant antibacterial activity against S. aureus