Polyketides, diketopiperazines and an isochromanone from the marinederived fungal strain Fusarium graminearum FM1010 from Hawaii

UZ ZAMAN, K. H. A.; SAROTTI, A.M.; WU, X.; CAO, S.*

PHYTOCHEMISTRY

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2022 vol. 198 p. 113138 - 113146

0031-9422

The fungal strain Fusarium graminearum FM1010 was isolated from a shallow-water volcanic rock known as ?live rock? at the Carl Smith Beach, Hilo, Hawaii. Eleven specialised metabolites, including two undescribed diketopiperazines, three undescribed polyketides, and one undescribed isochromanone, along with five known fusarielin derivatives were obtained from F. graminearum FM1010. The structures of the six undescribed compounds were elucidated by extensive analysis of NMR spectroscopy, HRESIMS, chemical reactions, and electronic circular dichroism (ECD) data. Kaneoheoic acids G-I showed mild inhibitory activity against S. aureus withthe MIC values in the range of 20?40 μg/mL when assayed in combination with chloramphenicol (half of the MIC, 1 μg/mL), an FDA approved antibiotic. Kaneoheoic acid I exhibited both anti-proliferative activity against ovarian cancer cell line A2780 and TNF-α induced NF-κB inhibitory activity with the IC50 values of 18.52 and 15.86 uM, respectively.