Open field exposure facilitates recovery from an aversive emotional event: Involvement of adrenergic and cholinergic transmitter systems

PSYDERLLIS M; PAUTASSI R.M; JUSTEL N

NEUROSCIENCE LETTERS

ELSEVIER IRELAND LTD

Lugar: Amsterdam; Año: 2016 vol. 633 p. 202 - 209

0304-3940

Successive negative contrast (SNC) is an incentive relativity procedure that has been widelyused to model emotional reactivity in rodents. The reward downshift experienced during SNCis thought to result in frustration. The exploration of a novel open field (OF), a complexsituation involving stress induction and novelty detection, can enhance or block theacquisition of associative and non-associative memories. Previous experiments found amodulatory effect of OF, applied before downshift trials, on SNC. This schedule, however,can affect retention performance by influencing attentional, motivational, motor or sensoryperceptualmechanisms at training or retention testing. The use of post-training OF exposureavoids these confounds. This work assessed the effect of OF exposure after the acquisitionof the downshifted memory, with the goal of targeting the consolidation of this mnemonictrace. We also investigated the involvement of the cholinergic and adrenergic systems in thisphenomenon. The results indicated that OF facilitates recovery from reward loss and thatboth transmitter systems, cholinergic and adrenergic, play a role in this effect of OF.