Plasminogen activator inhibitor 1 as marker of target organ damage

SCICOLONE A,; CRESPI N; SANCHEZ V; SCICOLONE G; VICENTE J; LIPSZYC P

Madrid.

Congreso; European Meeting on Hypertension. European Society of Hypertension.; 2006

European Society of Hypertension

SIXTEENTH EUROPEAN MEETING OF HYPERTENSION Madrid, June 12-15, 2006 – IFEMA- Feria de Madrid PLASMINOGEN ACTIVATOR INHIBITOR 1 AS MARKER OF TARGET ORGAN DAMAGE Authors:  Dr. Scicolone A., Dr. Crespi N., Dr. Sánchez V., Dr. Scicolone G., Ferando G., Dr. Vicente J., Dr.Lipszyc P. INSTITUTE OF CELL BIOLOGY AND NEUROSCIENCES. SCHOOL OF MEDICINE. UNIVERSITY OF BUENOS AIRES -ARGENTINE SECRETARY OF PUBLIC HEALTH, SAN MARTIN DIEGO THOMPSON HOSPITAL, SAN MARTIN Background: Plasminogen Activator Inhibitor 1 (PAI 1) have been related to bad prognosis in hypertensive patients. Aims: To establish whether there is a relationship between the plasma levels of PAI 1 activity and the target organ damage in patients with essential hypertension. To study whether there is a relationship between the plasma levels of PAI 1 activity and the stage 1 or 2 of hypertension. To study patients with and without cardiac and renal dysfunction. Methods: PAI 1 activity was assayed in plasma samples of 51 patients ( free of treatment) with essential hypertension by using an ELISA kit.  The sample was divided:(Seventh report of the Joint American Committee on High Blood Pressure) patients with target organ damage, patients with renal and cardiac dysfunction and  the ones with stage 1 or 2 of hypertension Values of PAI 1 activity were compared between the  different subgroups. Results:Comparison of age between patients with hypertension I (n: 26) and patients with hypertension II (n:25) shows that there is no significant difference between these two groups (p=0.247). Comparison of plasmatic PAI-1 activity between patients with hypertension stage I (n: 26) and patients with hypertension stage II (n: 25). shows that PAI-1 activity is significantly higher in patients with hypertension II (p<0.0312).Comparison of plasmatic PAI-1 activity between patients without lesion of target organ (n: 14) and patients with lesion of target organ (n: 37). Shows a tendency in which PAI-1 activity is higher in patients with lesion of target organ but this difference does not reach to be statistically significant (p>0.05). Comparison of plasmatic PAI-1 activity among patients with hypertension I without lesion of target organ (n: 6), patients with hypertension I and lesion of target organ (n: 20), patients with hypertension II without lesion of target organ (n: 8), and patients with hypertension II and lesion of target organ (n: 17). shows that the PAI-1 activity increases progressively from the first to the fourth group. ANOVA test shows that this variation is statistically significant (p=0.0441) and Tukey’s multiple comparison post ANOVA test shows that there is a significant difference (p<0.05) between the group with hypertension I without lesion of target organ and the group with hypertension II and lesion of target organ. This demonstrates that the group of patients with the highest degree of severity of hypertension presents plasmatic PAI-1 activity significantly higher than the group of patients with the lowest severity of hypertension. Comparison of plasmatic PAI-1 activity between patients with cardiac failure (n: 8) and  patients with normal ventricular systolic function (n: 43). that there is no significant difference between these two groups (p>0.05). Comparison of plasmatic PAI-1 activity among patients with hypertension I with normal renal function (n: 20), patients with hypertension I and renal failure (n: 7), patients with hypertension II with normal renal function (n:19), and patients with hypertension II and renal failure (n: 5). No significant difference could be detected (p>0.05). Conclusion: In the sample studied we could establish a relationship between the stage of hypertension and the PAI-1 activity. Higher levels of PAI 1 activity and the degree of target organ damage showed a  not significant tendency