Confocal Raman spectroscopy assisted by chemometric tools: A green approach for classification and quantification of octyl p-methoxycinnamate in oil-in-water microemulsions

SILVA DO NASCIMIENTO, D.; VOLPE, V.; FERNANDEZ, C.J.; ORESTI, G.M.; ASHTON, L.; GRUNHUT, M.

MICROCHEMICAL JOURNAL

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2023 vol. 184

0026-265X

This work proposes a green analytical method based on confocal Raman spectrometry and chemometrics tools for the qualitative and quantitative analysis of oil in water microemulsions loaded with the UVB filter octyl pmethoxycinnamate (OMC). The method does not use reagents and only 10 µL of sample are needed. The analyzed microemulsion samples were synthetized in the laboratory using decaethylene glycol mono-dodecyl ether (21.9 %) as non-ionic surfactant, ethyl alcohol (7.3 %) as co-surfactant, oleic acid (1.5 %) as oil phase and water (69.3 %). A physicochemical characterization of the samples was carried out obtaining expected values for droplet size (