INVESTIGADORES
RUBIO Maria Fernanda
congresos y reuniones científicas
Título:
ADIPOCYTES IN THE BREAST CANCER MICROENVIRONMENT: DIFFERENT TUMOR CELLS, DIFFERENT WAYS TO RESPOND
Autor/es:
LIRA, MC; ROSA, FD; BALDI, ME; SOARES MACHADO, M; PALMA, A; MARINO, GI; COSTAS, MA; RUBIO, MF
Lugar:
On line
Reunión:
Congreso; REUNIÓN ANUAL DE SOCIEDADES DE BIOCIENCIA 2020; 2020
Institución organizadora:
Sociedad Argentina de Investigación Clínica
Resumen:
Adipocytes are considered to be critical in the tumoral microenvironmentof breast cancer. However, most studies have focusedon linking obesity and cancer, ignoring changes on normal adipocytes.Therefore, we retrieved microarray data from a GEO dataset(GSE95827) to analyse transcriptional changes in 3T3-L1adipocytes after 3 days of co-culture with MCF7 (Ad+MCF) or MDAMB-231 breast cancer cell (Ad+MDA).By GEO2R tool, we determined 245 up-regulated genes in Ad+MCF7and 215 in Ad+MDA compared to adipocytes alone (p
