LEPTIN EFFECTS ON THE EXPRESSION OF RAC3 COACTIVATOR

IARA CASTELLANOS; FRANCISCO DAMIÁN ROSA; MARÍA CECILIA LIRA; JULIANA LOURDES BERNACCHIA; MARÍA FLORENCIA QUINTANILLA; ALEJANDRA GRACIELA PALMA; MÓNICA ALEJANDRA COSTAS; MARÍA FERNANDA RUBIO

Mar del Plata

Congreso; REUNIÓN CONJUNTA SAIC SAB AAFE AACYTAL 2023; 2023

SAIC

Adipocytes account for the largest proportion among the cells thatcomprise breast tissue. Although they are considered to be a criticalcell type in the tumor microenvironment of breast cancer, it is stillunclear the molecular mechanisms that control their behavior in thiscontext. We have demonstrated that the expression of the coactivatorRAC3 decreases during adipogenesis and was increased inadipose tissue adjacent to breast tumors. Therefore, the aim of thiswork was to study if leptin was able to modulate RAC3 expression.From the systematic review of 20 papers, we confirmed the associationbetween serum leptin levels and the presence of breastcancer in postmenopausal women (test for overall effect Z=11.98,p