ASSOCIATION OF PRL-3 AND P21 IN EXPERIMENTAL PITUITARY TUMORAL MODEL: A POSSIBLE NEW TUMOR GROWTH REGULATION

MOYANO CRESPO G. D.; CECENARRO L.; PEREZ P.; GUIDO C.; PICECH F.; SOSA L.; GUTIÉRREZ S.; PETITI J.P.; TORRES A.; MUKDSI J. H.

Congreso; 19 International Congress of Endocrinology; 2021

Introduction: PRL-3 is a subclass of a protein tyrosine phosphatase super family which is expressed in a wide range of epithelial neoplasms. However, up to now, PRL-3 has not been described in the pituitary.Objectives: Our aim was to evaluated PRL-3 expression. p53, p21, Ki67 were also analyzed. Methods: Fisher male rats treated with estradiol benzoate (EB) during 10, 20 and 30 d (n: 9) were used. Rat normal pituitaries (n:3) were use as control (C). Analysis of PRL-3, p21, p53 and Ki67 expression was performed by Immunohistochemistry at photonic and electronic level and Western Blot. Statistical analysis: Anova-Fisher and Pearson?s correlation.Results: P21 was increased in the experimental model, reaching the highest values at 30 EB (adenomatous state) compared to C (p