Acute antioxidant effect of glucocorticoids improve cardiac function following ischemia/reperfusion

ESCUDERO, DAIANA; FANTINELLI, JULIANA C; MARTINEZ, VALERIA; PEREZ NÉSTOR; DIAZ RG

Mar del Plata

Congreso; Reunion conjunta de biociencias; 2022

Introduction: Glucocorticoids (GCs) are steroid hormones involved in several physiological processes including cardiovascular function. The endogen GC cortisol as well as the synthetic ones both exhibit the ability to bind and activate either the GC receptor (GR) or the mineralocorticoid receptor (MR), highly expressed in cardiac tissue. Experimental results have provided evidence that overstimulation of the cardiac MR promotes ventricular remodeling and proarrhythmogenic effects leading to myocardial dysfunction. Furthermore, reliable data suggest that such deleterious effects involve a novel non-genomic signaling pathway that ends with a hyperactivation of the cardiac sodium-hydrogen exchanger (NHE1). Despite the extensive characterization of MR signaling, little is known about the effects of GR activation in cardiac tissue. In this line, this study was aimed to evaluate whether acute GCs may protect the myocardium against ischemia/reperfusion injury (I/R).