Electrospray deposition of fumaric copolymer for transdermal delivery devices

CHAMBI, MARÍA; BRAVI COSTANTINO, LETICIA; OBERTI, TAMARA; PERUZZO, PABLO J.

Mar del Plata

Simposio; XVI SIMPOSIO LATINOAMERICANO DE POLÍMEROS Y XIV CONGRESO IBEROAMERICANO DE POLÍMEROS; 2018

INTEMA

Over the last years, an extensive research effort has been directed toward developing membranes to specific biomedical applications, such as drug delivery, tissue regeneration, and coating for medical devices1 among others. In particular, the drug delivery systems have been designed to deliver a drug to a specific site, in specific time and release pattern, in order to avoid multiple doses and bypassing of the hepatic ??first-pass?? metabolism. Different kind of polymeric materials have been used for designed membranes, such as polyisobutilenes, polysiloxanes, acrylic copolymers. Polyfumarates have been previously studied in our group as scaffolds. Due to their properties, they can be considered candidates to replace commercial polymer used in transdermal drug delivery (TDD). Recently, our research group developed a risedronate (bisphosphonates used in osteoporosis treatment) releasee system from a matrix obtained by solvent casting based on copolymers obtained from vinyl acetate (VA) and dioctyl fumarate (DOF)2. With the objective of modified the release rate observed in this system, this work presents the production of a TDD membrane by electrospraying.