ANTITUMORAL ACTIVITY OF NEW CHEMICAL COMPOUNDS IN MURINE TUMOR MODELS

GIORDANO, R; MARTINEZ AMEZAGA, M; PRADA GORI, D. N.; CAMACHO, C. M.; CORNIER, P.G.; BOGGIAN, D. B.; DELPICCOLO, C. M. L.; BAGLIONI, M. V.; MAINETTI, L. E.; SCHAROVSKY, O. G.; ROZADOS, V.; RICO, M.

Congreso; SAIC 2018; 2018

Our aim was to evaluate the antitumor activity of families of new synthesised compounds: 12 oxadiazoles and 13 propargylamines. The in vitro effect of the compounds on viability was initially evaluated on 4T1 mammary adenocarcinoma, and MC3T3e1 normal osteoblastic murine cell lines, at 100 μM. Then, there were selected 2 propargylamines (MMA06 and MMA4210f3) that showed more than 50% inhibition of cell viability, with respect to the non-treated control without affecting normal cells, while the oxadiazoles exhibited more than 50% decrease on viability of tumor and normal cells.