Involvement of ER stress and MAPK pathways in the apoptotic effect induced by a triazolyl peptidyl penicillin in murine melanoma cells

BELLIZZI, Y.; CORNIER, P.G.; DELPICCOLO, C. M. L.; BOGGIAN, D. B.; MATA, E. G.; BLANK, VIVIANA; ROGUIN, L. P.

Congreso; SAIC 2018; 2018

The triazolylpeptidyl penicillins (TAPs) behaves as a selective and potent antitumor agent that induces an apoptotic response. In order to further investigate the mechanism of action of this compound, we examined the possible contribution of the ER stress in the cell death process.