Nanotoxicology Characterization of Carbamazepine-Dendrimers Complexes

IGARTUA DE; MARTINEZ CS; ALONSO SDV; PRIETO MJ

Simposio; LAZEN 2016 - IV Latin American Zebrafish Network Course and Symposium; 2016

Carbamazepine (CBZ) is on the market as an antiepileptic. It also has potential uses for the treatment of numerous neurodegenerative diseases. However, it has low solubility in aqueous media, inefficient pharmacokinetic profiles and multiple side effects, so it is important to avoid widespread distribution. Drugs delivery systems (DDS) have gained relevance in the field of nano- and bio-medicines. PAMAM dendrimers (D) generation 4.0 and 4.5 (DG4.0 and DG4.5) are optimal polymers as DDS that would increase the solubility of CBZ and the arrival to the brain.Our objective was to characterize complexes between CBZ and dendrimers (D-CBZ) and to study their nanotoxicity for both human health and environmental risk during productionTRABAJO PREMIADO