PERSONAL DE APOYO
CAPPELLETTI Ariel Leonardo
artículos
Título:
Transferrin Decorated Thermoresponsive Nanogels as Magnetic Trap Devices for Circulating Tumor Cells
Autor/es:
MAZDAK ASADIAN-BIRJAND; CATALINA BIGLIONE; JULIAN BERGUEIRO; A.L. CAPPELLETTI; CHINMAY RAHANE; GOVIND CHATE; JAYANT KHANDARE; BASTIAN KLEMKE; MIRIAM C. STRUMIA; MARCELO CALDERÓN
Revista:
MACROMOLECULAR RAPID COMMUNICATIONS
Editorial:
WILEY-V C H VERLAG GMBH
Referencias:
Lugar: Weinheim; Año: 2016 vol. 37 p. 439 - 445
ISSN:
1022-1336
Resumen:
A rational design of magnetic capturing nanodevices, based on a specifi c interaction with circulating tumor cells (CTCs), can advance the capturing effi ciency and initiate the developmentof modern smart nanoformulations for rapid isolation and detection of these CTCs from the bloodstream. Therefore, the development and evaluation of magnetic nanogels (MNGs) based on magnetic nanoparticles and linear thermoresponsive polyglycerol for the capturing of CTCs with overexpressed transferrin (Tf + ) receptors has been presented in this study. The MNGs aresynthesized using a strain-promoted ?click? approach which has allowed the in situ surface decoration with Tf?polyethylene glycol (PEG) ligands of three different PEG chain lengths as targeting ligands. An optimal value of around 30% of cells captures is achieved with a linker ofeight ethylene glycol units. This study shows the potential of MNGs for the capture of CTCs and the necessity of precise control over the linkage of the targeting moiety to the capturing device.