Magnetic nanoparticles of La0.78Sr0.22MnO3, coated with SiO2: preparation and cytotoxicity in human cell cultures.

LASSA MA SILVINA; GAMARRA LUQUEZ, CARLOS; ALBORNOZ, CECILIA; LEYVA, GABRIELA A.; VARGAS ROIG, LAURA MA.; VAZQUEZ PATRICIA G

Procedia Materials Science

elsevier

Año: 2015

2211-8128

Nanomedicine is a great interesting area for use of magnetics nanoparticles. Among their main applications we can highlight, for example, its use as contrast agents for magnetic resonance imaging, or cellular delivery, or cellular hyperthermia, employed in oncology. This study aimed to determine whether the magnetic nanoparticles with La0.78Sr0.22MnO3 (LSMO), coated with SiO2 are cytotoxic to the cancer cell line MCF-7 (human breast adenocarcinoma). The nanoparticles used were synthesized and characterized in the Laboratory of Condensed Matter Physics (CAC-CNEA). For the synthesis of the perovskite LSMO liquid-mix method was used and the sol gel method was used for SiO2 coating. Cytotoxicity and clonogenic viability assays were assessed using crystal violet staining and subsequent counting colonies. The idea of using magnetic particles to destroy tumors is not new, it was proposed by Gilchrist in 1957 (Grande 2007). However,  there have been developed many different types of magnetic carriers, even today, the poor selectivity for tumor cells, the possibility of side effects due to the accumulation and the toxicity of these carriers are major limitations. In addition, some materials that show promise in trials "in vitro" are negative "in vivo". The results are discussed in depth in the complete work.