Superantigens of the EGC operon: SEG, SEI, SEO and SEM differential effect on IL-6 signal transducer (GP130), IL-17 release and gamma/delta T cells

NOLI TRUANT, SOFIA; IANNANTUONO LÓPEZ LAURA; REDOLFI DANIELA; SARRATEA MARÍA BELÉN; ANTONOGLOU MARÍA BELÉN; MALCHIODI EMILIO; JANCIC CAROLINA; FERNÁNDEZ MARISA

Mar del Plata

Congreso; 66 Reunión Anual de la Sociedad Argentina de Inmunología; 2018

SAI - SAIC

Superantigens (SAgs) are enterotoxins that promote massive cyto¬kine release and immunosuppression. Most of them are produced by extracellular bacteria, such as S. aureus and S. pyogenes. IL-17 is a crucial cytokine in the eradication of these pathogens. Here, we investigated the effect of four egc operon natural SAgs (SEG, SEI, SEO and SEM) on the innate immunity and its IL-17 arm.SAgs induce production of higher concentrations of IL-6 (ELISA) on PBMCs compared to control (p