Potential role of hypothalamic tanycytes mediating the blood transport of ghrelin

URIARTE M., DE FRANCESCO. N, FERNANDEZ G., CABRAL A., GARCIA ROMERO G., REYNALDO M., PERELLO M., LUFRANO D.

Congreso; 2d FALAN Congress; 2016

Ghrelin is a 28-amino acid octanoylated peptide hormone secreted from the stomach that mainly acts in the central nervous system to regulate food intake and neuroendocrine axis. However, the accessibility of plasma ghrelin to the brain is limited and restricted to few specific brain areas.The goal of this study was to gain insights into the system mediating the transport of circulating ghrelin to the brain in mice.For this purpose, we used a fluorescent ghrelin tracer (F-ghrelin) that was centrally or peripherally injected to mice and mapped its distribution within the blood-cerebrospinal fluid barrier (the choroid plexus, CP, and the tanycytes of the median eminence, ME)