Modified chitosan for the purification of proteins with potential biopharmaceutical applications

URTASUN, NICOLÁS; BAIELI, MARÍA FERNANDA; HIRSCH, DANIELA BELÉN; BRACCO, LAUTARO FIDEL; MIRANDA, MARÍA VICTORIA; CASCONE, OSVALDO; WOLMAN, FEDERICO JAVIER

Jornada; I Jornada de Divulgación de las Actividades del Departamento de Microbiología, Inmunología, Biotecnología y Genética; 2018

Facultad de Farmacia y Bioquímica, Universidad de Buenos AIres

Chitosan is a plysaccharide derived from the deacetylation of chitin (the second most abudant polymer after cellulose). Chitosan is soluble in acid medium and insoluble in basic medium and can be easily handled, formatted and chemically modified to be used in variety of applications in food, pharmaceutical and material fields. Here we report the production of highly porous chitosan mini-spheres and membranes, and their chemical modification to perform low-cost protein purification processes.