Resveratrol modulates ATPase activity of liposome-reconstituted ABCG1

DE ATHAYDE MONCORVO, A; CORBALÁN, N; HOMOLYA, L; MORERO, R; MINAHK, C

FEBS LETTERS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2013 vol. 587 p. 2359 - 2363

0014-5793

ABCG1 is a half-sized transporter with an unquestionable importance in cholesterol homeostasis. So far, its expression and thus its activity was suggested to be regulated at transcriptional level by LXR and PPARs agonists including polyphenols. But it is unknown whether there are other mechanisms of up-regulation of ABCG1 activity. In the present work resveratrol was shown to induce a nearly 2-fold increase in ATPase activity of reconstituted ABCG1. Evidence is presented for the first time suggesting that resveratrol is able to activate ABCG1 activity by an alternative mechanism that involves an indirect interaction.