Association of PRL-3 and P21 in experimental pituitary tumoral model: a possible new tumor growth regulation.

MOYANO CRESPO G D; CECENARO L; PEREZ P; GUIDO, C; PICECH, F; SOSA L DEL V.; GUTIÉRREZ, S; PETITI J P; TORRES, A I; MUKDSI, J. H.

Buenos Aires

Congreso; ICE2021Virtual-19th International congress of Endocrinology-4th Latin American Congress of Endocrinology (CONLAEN)-13th Congress of the Argentine Federation of Endocrinology Societies (FASEN); 2021

Introduction: PRL-3 is a subclass of a protein tyrosine phosphatase super family which is expressed in a wide range of epithelial neoplasms. However, up to now, PRL-3 has not been described in the pituitary.Objectives: Our aim was to evaluated PRL-3 expression. p53, p21, Ki67 were also analyzed. Methods: Fisher male rats treated with estradiol benzoate (EB) during 10, 20 and 30 d (n: 9) were used. Rat normal pituitaries (n:3) were use as control (C). Analysis of PRL-3, p21, p53 and Ki67 expression was performed by Immunohistochemistry at photonic and electronic level and Western Blot. Statistical analysis: Anova-Fisher and Pearson?s correlation.Results: P21 was increased in the experimental model, reaching the highest values at 30 EB (adenomatous state) compared to C (p