Effects of fructose rich diet in reproductive age of murines females: lack of insulin-resistence and systolic cardiac alterations

ILLANES A; LOFEUDO J; CASTRO C; BLANCO P; DE GIUSTI V; PALOMEQUE J

La Plata

Congreso; Congreso anual de la International Society for Heart Research Sección Latinoamericana; 2022

Previously we have reportedthat male rats and mouse, after a fructose rich diet (FRD), showed impaired glucose tolerance (IGT), insulin-resistance (IR) and cardiac defects, such us hypertrophy, systolic dysfunction and arrhythmias. In the present work we aim to identify the effects of the same diet in females rat and mouse. We used females Wistar rats and mice, fed with a FRD or control diet (CD) for 21 days. Morphometric parameters did not show any difference at corporal weight, abdominal or retroperitoneal fat (normalized either by corporal weight, CW, or tibial length, TL).However, the normalized heart weight showed a significant increase in the FRD mice vs the CD (p:0.05/PC o 0.03/LT). The biochemical analysis showed that FRD rats did not present IR (glycaemia/triglyceridesindex) neither an impaired intraperitoneal tolerance glucose test with respect to CD animals.By echocardiography, only the diameter of interventricular septum in diastole and systole(p: 0.053 y 0.053), and the posterior wall in diastole and systole (p. 0.022 y 0.030), were significant different, indicating a cardiac hypertrophyin FRD vs CD animals. There was not a significant difference in the fractional shortening, although there was a decreasedmarked trend in the E/A ratio, which may indicate an alteration in the ventricular relaxation in the FRD vs CD mice.The FRDin females murine, at the contrary of the males, did not show IGT or IR, although we can observe cardiac hypertrophy without systolic dysfunction, indicating, may be, a protection againstdiets with excess ofcarbohydrates, in the reproductive age with respect to males.