Anti-Ro/SSA and M3 muscarinic acetylcholine receptor antibodies in primary Sjögren?s Syndrome with an altered corrected QT interval

SILVIA REINA; ENRI BORDA

Clinical and Experimental Immunology

British Society for Immunology

Lugar: London; Año: 2013

1365-2249

Previous studies have demonstrated that antibodies against muscarinic acetylcholine receptors (mAChRs) from exocrine glands correlate with Sjögren?s syndrome (SS) in the majority of patients. The aim of the present investigation was to establish whether serum IgG and anti-Ro/SSA antibodies present in SS interact with IL-1β or PGE2 and if so whether they affect the corrected QT interval. Results show that the presence of active anti-Ro(+) antibodies in the serum of pSS patients is associated with increased serum levels of anti-M3 mAChR antibodies. Functional studies revealed that the presence of anti-Ro(+) antibodies and anti-M3 mAChR antibodies accompanies increased production of serum IL-1β and PGE2. The immune cytokine IL-1β could be, in part, responsible for the alteration in QTc while the level of the pro-inflammatory mediator PGE2 may correspond to the severity of the inflammatory process occurring at the glandular level through the action of these muscarinic autoantibodies. The results support the notion that serum anti-Ro and anti-M3 autoantibodies in SS patients may be one factor that can trigger an alteration in QTc interval with direct participation of increased levels of serum IL-1β and PGE2 in Ro(+) pSS patients.