INTA CATTLE-GUINEA PIG CORRELATION MODEL IMPLEMENTATION AS AN OFICIAL CONTROL FOR INMUNOGENIC QUALITY BOVINE IBR VACCINE

BARROS, VIRGINIA; RODRIGUEZ, DANIELA; GONZALEZ THOMAS, VALERIA; MARANGUNICH, LAURA; LOPEZ, MARIA VIRGINA; D'ALOIA, RICARDO; MARADEI, EDUARDO; FERNANDEZ, FERNANDO; PARREÑO, VIVIANA

Buenos Aires

Simposio; Symposium: Practical Alternatives to reduce animal testing in quality control of veterinary biologicals in the Americas.; 2010

IABS-OIE

INTA CATTLE-GUINEA PIG CORRELATION MODEL IMPLEMENTATION AS AN OFICIAL CONTROL FOR INMUNOGENIC QUALITY BOVINE IBR VACCINE. Barros, Virginia G.1; Rodríguez, Daniela2; Marangunich, Laura3; Gonzalez Thomas, Valeria1; Lopez, Virginia4; D’Aloia, Ricardo; Maradei, Eduardo1; Fernández,  Fernando2 y Parreño Viviana2. vbarros@senasa.gov.ar   1 DILAB-SENASA, Coord. de Virología, D. de Control de Vacunas; 2Intituto de Virología, CICV y A, INTA Castelar, 3UNTREF (Universidad Nacional de 3 de Febrero), 4Facultad de Agronomia – UBA.  In our country, bovine combined inactivated vaccines are released to the market to prevent respiratory and reproductive viral infection including bovine herspesvirus type 1 (BoHV-1), ethiolgic agent of Infectious bovine rhinotracheitis (IBR) and co-agent of infectious bovine cheratoconjuntivitis. Is extremily important to find a standarized assay in laboratory animals that could evaluated comparatively each vaccine batch potency, in a harmonized way, to guarantee the presence of effective market products. SENASA began his research considering the strenght reached by the cattle-guinea pig correlation model developed by INTA for  potency IBR vaccines. During the last to years random market vaccines were evaluated by SENASA. Our purpose is the adoption of this guina pig model as an oficial control for the approbation-rejection of IBR vaccines. Guinea pig model is also alligned with 3R principles. Up to date, the results finding in market vaccines are hopeful taking into account their repeatability, easy reproducibility, non valent formulation variation and could be suitable to acquous as oil emulsions. Therefore, guine pig potency test implementation will allow improve and update the valid rules focus on the oficial requirement to release combined inactivated viral vaccine batch without cattle use and reducing animal laboratory number.