• Mouse, guinea pig and calf models to evaluate the potency and efficacy of passive strategies to prevent rotavirus diarrhea

PARREÑO, VIVIANA; GARAICOECHEA, LORENA; RODRIGUEZ, DANIELA; VEGA, CELINA; LOPEZ, MARIA VIRGINA; VENA, MARÍA MARTA; MARANGUNICH, LAURA; DUS SANTOS, MARIA JOSE; SAIF, LINDA J.; FERNANDEZ, FERNANDO

Buenos Aires

Simposio; Symposium: Practical Alternatives to reduce animal testing in quality control of veterinary biologicals in the Americas.; 2010

IABS OIE

Mouse, guinea pig and calf models to evaluate potency and efficacy of passive strategies to prevent Rotavirus diarrhea.  Viviana Parreño1; Lorena Garaicoechea1; Celina Vega1; Daniela Rodriguez1;  Maria V. Lopez2; Maria M. Vena3; Laura Marangunich4; Maria J. Dus Santos1; L. Saif5 and F. Fernández1. vparreno@cnia.inta.gov.ar 1Instituto de Virología, CICV y A – INTA. 2Universidad de Buenos Aires, Facultad de Agronomía. 3Biogénesis Bagó S.A. 4Universidad Nacional de Tres de Febrero, UNTREF, Argentina. 5Food Animal Health Research Program (FAHRP),The Ohio State University, USA. Group A Bovine Rotavirus (BRV) is the major cause of neonatal diarrhea in human infant and the young of food animal species, worldwide. The prevention of the disease in the veterinary field is based on passive strategies.  The first strategy is the vaccination of the mother in the last stage of pregnancy to increase the levels of passive maternal antibodies in the offspring after colostrum intake. The second strategy is the supplementation of the diet with passive antibodies. We summarized here the used of three models: i) a suckling mouse model, ii) a guinea pig model and iii) a calf model to evaluate vaccine immunogenicity and the efficacy of different passive strategies (vaccination and diet supplementation with homologous and heterologous antibodies) to control rotavirus diarrhea.