INVESTIGADORES
CAMPELO Adrian Esteban
congresos y reuniones científicas
Título:
INTRACRINOLOGY: VASCULAR ENDOTHELIUM AS TARGET OF DEHYDROEPIANDROSTENEDIONE ACTION
Autor/es:
CAMPELO, ADRIÁN; CUTINI, PABLO; MASSHEIMER, VIRGINIA
Lugar:
Buenos Aires
Reunión:
Congreso; LXII Reunión Científica anual de la Sociedad Argentina de investigación Clínica; 2017
Institución organizadora:
Sociedad Argentina de Investigación Clínica
Resumen:
According to intracrinology, active sex steroid hormones can be lo-cally synthesized from their precursor Dehydroepiandrostenedione (DHEA). In vascular system sex hormones regulate cell migration, proliferation, production of nitric oxide (NO) and adhesion of platelets (PT) and monocytes to endothelial cells (EC). We evaluated the effect of DHEA on these events and evaluated if they were assessed by DHEA, or if conversion to other sex steroids is required. Primary cultures of rat aortic EC were obtained from Wistar rats and exposed to DHEA (20nM-2mM 0.5-48h). DHEA stimulated NO production (Griess reaction 0.17±0.02; 0.24±0.04; nmols NO/mg prot, Cont; DHEA p
