Cellular and molecular actions of testosterone in vascular system

CAMPELO A, MONTT GUEVARA M, SIMONCINI T, MASSHEIMER V

Bruselas

Congreso; 10Congress of the European Society of Gineclogy; 2013

European Society of Gineclogy

Vascular function is regulated by various agonists including the sex steroid hormones estrogen, progesterone and androgens. In order to contribute to the knowledge of the role of androgens on vascular function, in this work we investigated the cellular and molecular actions of testosterone (T) on the regulation of cellular events involved in vascular physiology such as nitric oxide (NO) production, proliferation and migration of rat aortic endothelial cells (EC). We provide evidence that T (10-7 a 10-11M) induces an acute stimulation of NO production in EC (15 to 125% above/control, p