Androgen regulations of cellular events involve in bone perfusion

CAMPELO A; CUTINI P, RAUSCHEMBERGER M, MASSHEIMER V

Buenos Aires

Congreso; XXIX Annual Meeting of the Argentine Association of Osteology and Mineral Metabolism; 2012

Asociación Argentina de Osteología y Metabolismo Mineral

We studied the effect of Testosterone (T) on nitric oxide (NO) production, endothelial cell (EC) migration and VEGF synthesis; key factors for bone perfusion and vascularization. We previously reported that in rat aortic strips 1-20 min treatment with T (0.01-100 nM) significantly increased NO production in a non gender specific manner. We found that the stimulatory action of T on NO synthesis decreased with age (7.84±0.83 vs 3.82±0.60 nmol NO/mg prot, young vs adult, p